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Benzene derivatives and pharmaceutical composition

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专利名称:Benzene derivatives and pharmaceutical

composition

发明人:Yanaka, Mikiro,Nishijima, Fuyuhiko,Enari,

Hiroyuki,Dewa, Toshikazu,Yamazaki,Toru,Ise, Michihito

申请号:EP95108406.0申请日:19950601公开号:EP06870A2公开日:19951206

摘要:A benzene derivative of the formula (I) : wherein R is hydrogen, C-alkyl, C-haloalkyl, -NH, -NHR ; R is hydroxyl, -OR, three- to seven-membered saturatedcycloaliphatic amino optionally interrupted by one or more nitrogen, oxygen or sulfuratoms, -NHR, -N(R), -NH; R is hydrogen, C-alkyl, or -C(=O)R; R is -CO-, -SO-; R is -CO-,single bond; R is R-R5; R is -N(R)-, -NH-, -O-, -N(R)-, -N(C(=O)R)-, -N(C(=O)NH)-, -N(C(=O)NHR28)-; R is hydrogen, C-alkyl, C-haloalkyl, -NHC(=O)(CH)CH, -NHC(=O)R, -NHC(=O)CH(CH), -NH, -NHR, -(CH)CH; Z is C, CH, N ; A is CH, N ; R is hydrogen, -CHCHCOOH, -CHCHCOOR, -CHCH0H, -CHCH0R, -CHCHNH, -CHCHN(R), -CHCH-azole, -CHCHNHR, -CHCHCHR ; R is azole, -COOH ; R to R are independently C-alkyl or C-haloalkyl ; m is 0 to 6 ; n is 0 to 6 ; t is 0 or 1, with the proviso that when Z is N, R ishydrogen, -CHCHCOOH, -CHCHCOOR, -CHCH0H, -CHCHOR, -CHCHNH, -CHCHN(R), -CHCH-azole, or -CHCHNHR, or a salt thereof, and a pharmaceutical compositioncomprising said benzene derivative or a pharmaceutically acceptable salt thereof, and apharmaceutically acceptable carrier are disclosed.

申请人:Kureha Chemical Industry Co., Ltd.

地址:9-11, Nihonbashihoridome-cho 1-Chome, Chuo-ku Tokyo 103 JP

国籍:JP

代理机构:Cohausz & Florack

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