Regulators of the hedgehog pathway, compositions a

专利名称：Regulators of the hedgehog pathway,

compositions and uses related thereto

发明人：Henryk Dudek,Benxiu Ji申请号：US09867311申请日：20010529

公开号：US20010034337A1公开日：20011025

摘要：The present invention makes available methods and reagents for inhibitingaberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function orsmoothened gain-of-function comprising contacting a cell with a compound, such as apolypeptide or small molecule in an amount sufficient to control the aberrant growthstate e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehogactivity. The present invention further makes available methods and reagents forameliorating to consequences of hedgehog loss-of-function, ptc gain-of-function, orsmoothened loss-of-function comprising contacting a cell with a compound, such as apolypeptide or small molecule, in an amount sufficient to ameliorate the In certainembodiments, the subject compounds, e.g., a cAMP analog, adenylate cyclase agonist, orcAMP phosphodiesterase inhibitor, regulate cAMP levels, which in turn modulates activityof the hedgehog pathway.

申请人：DUDEK HENRYK,JI BENXIU

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