CVS TRANSPLANTATION FOR TREATMENT OF BACTERIAL VAG

专利名称：CVS TRANSPLANTATION FOR TREATMENT

OF BACTERIAL VAGINOSIS

发明人：ENSIGN, Laura,CONE, Richard,HANES, Justin申请号：EP158199.6申请日：20151210公开号：EP3233098A1公开日：20171025

摘要：Methods and materials for treating bacterial vaginosis (“BV”) are provided.Cervicovaginal secretions (“CVS”) from a woman with Lactobacillus crispatus-dominated(>50%) vaginal microbiota is transplanted to women with BV as a method for restoringbeneficial vaginal microbial communities and/or increasing resistance to sexuallytransmitted disease. Efficacy can be enhanced, or the properties of the endogenous CVSimproved, through administration of an acidifying agent such as lactic acid. The examplesdemonstrate the role of healthy CVS in disease resistance, and the effect of pH on CVSproperties. The examples also describe the collection and transplantation of healthybeneficial CVS into women at risk for, or after treatment for, BV.

申请人：The Johns Hopkins University

地址：3400 North Charles Street Baltimore, MD 21218 US

国籍：US

代理机构：Potter Clarkson LLP

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