Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Gemcitabine Hydrochloride122111-03-9HY-B0003299.66C9H12ClF2N3O4>98%Solubility:DMSO <1 mg/mL; Water 23 mg/mLMechanisms: Pathways:Cell Cycle/DNA Damage; Target:Nucleosideantimetabolite/analog gyBiological Activity:GemcitabineHcl (LY 188011 Hcl) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. IC50 Value: 50 nM( PANC1); 40 nM(MIAPaCa2); 18 nM(BxPC3 ); 12 nM(Capan2) Target: Nucleoside antimetabolite/analog Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- andtriphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing thedeoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting inDNA strand termination and apoptosis. Gemcitabine inhibits proliferation BxPC-3 pancreatic cancerppppcell line with IC50 of 0.06 μM....References:[1]. Lansakara-P., Dharmika S. P.; Rodriguez, B. Leticia; et al.Synthesis and in vitro evaluation ofnovel lipophilic monophosphorylated gemcitabine derivatives and their nanoparticles. InternationalJournal of Pharmaceutics (Amsterdam, Netherlands) (2012), 429(1-2), 123-134. [2]. Duenas-Gonzalez, Alfonso; Coronel, Jaime; Cetina, Lucely. Pharmacokinetic evaluation ofgemcitabine hydrochloride for the treatment of cervical cancer.Expert Opinion on Drug Metabolism &Toxicology (2011), 7(12), 1601-1612. [3]. Li, Yexia; Cao, Jinneng; Qi, Lihua; Gemcitabine (Gemzer) up-regulates expression of geneTusc2 and Lats2 in breast cancer mice. Jiepou Xuebao (2010), 41(6), 832-836. [4]. Ishii M, Nagaoka S, Tatsumi M, Kitagawa N, Taketsuna M, Okubo S, Maeda K, Takeuchi K. Sftfilfitbihdhlid(GEMZAR?)iJliiltdiGTKSafety profiles of gemcitabine hydrochloride(GEMZAR?)in Japanese clinical studiesGan To Ka...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr