Method for expression of small antiviral RNA molec

专利名称：Method for expression of small antiviral

RNA molecules within a cell

发明人：Xiao-Feng Qin,David Baltimore申请号：US10319341申请日：20021212公开号：US07195916B2公开日：20070327

摘要：In one aspect, the invention provides methods and compositions for theexpression of small RNA molecules within a cell using a retroviral vector. The methodscan be used to express double stranded RNA complexes. Small interfering RNA (siRNA)can be expressed using the methods of the invention within a cell, that interfere with aviral life cycle by down regulating either the viral genome, a viral genome transcript, or ahost cell that. In another aspect the invention provides methods for treating patientshaving suffering from infection, particularly infection with HIV. In a further aspect, theinvention provides methods for producing siRNA encoding lentivirus where the siRNAactivity may interfere with the lentiviral life cycle.

申请人：Xiao-Feng Qin,David Baltimore

地址：Pasadena CA US,Pasadena CA US

国籍：US,US

代理机构：Knobbe Martens Olson & Bear LLP

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