第4期 张宪香: 瑞香狼毒对小鼠细胞免疫功能的影响 533 D53何龙.细胞因子自分泌现象及其生理和病理意义[J].上海免疫学杂志,1994(3):184—187. D63王志宏,雷明盛,彭胜,等.杜仲黄酮对小鼠淋巴细胞增殖及IL一2和IFN一7诱生的影响[J].天然产物研究与开发,2016,28(4) 514—518. Effect of Stellera chamaej asme extract on the cellular immunity of mice ZHANG Xianxiang (Pharmacy Department of Jining Veterans Hospital,Jining 272101,China) Abstract:To investigate the effects of water and alcoholic extracts of S.chamaejasme on cellular im— munitv of mice.Water and alcoholic extracts of S.chamaejasme were prepared.The immunosup— pressive action was investigated through T lymphocyte proliferation in vitro.The mice were adminis— tered for 1 5 days consecutively(ig.)with the dosage according to body surface area.The delayed— type hypersensitivity(DTH)model of mice was used for investigation in vivo.The thymus and sDleen index of the mice were measured.The IL一2,IFN一7,IL一4,IL一6 levels in sera of normal animals were determined by ELISA.Water and alcoholic extracts of S.chamaejasme could inhibit concanaval— in A—induced T lymphocyte proliferation in vitro significantly.The alcoholic extract could suppress ear swellin【g degree of DTH mice.The higher dosage of alcoholic extract could inhibit the thymus in— dex.Furthermore,S.chamaejasme was found to affect the IL一2,IFN—Tlevel in sera.IL一2,IFN一7 lev— e1s in water and alcoholic extract administered groups were significantly lower than the control grouP.S.chamaejasme might show inhibitory effects on the cellular immunity of mice by decreasing the cytokine production of T cells. Key words:Stellera chamaejasme;lymphocyte proliferation;DTH;cytokine;immunosuppression I{●Illl◆ ◆ ◆lIIl◆ ◆ ◆_lll◆¨¨◆ ◆lIIl◆ ◆ ◆_I【l◆ ◆ ●l【【j◆II【I◆lllI◆ ◆…【◆ ◆…◆I◆ ◆ ◆I◆…◆I◆I◆l◆…◆…l◆…I◆…l◆…l◆…l◆…I◆…l◆…l◆…l◆ ◆…l◆川I◆Illl◆I◆Ill◆I 学术论文的标点符号及其用法 《辽宁师范大学学报(自然科学版)》标点符号的用法严格执行国家发布的《标点符号用法》,要点如下 a.句号用黑圆点表示. b.省略号用2个三连点,其后不必写“等”字;在数学式中只用1个三连点. C.波浪号“~”用于表示数值范围. d.一字线“一”用于表示起止或范围等. e.半字线“一”用于表示复合名词等. f.外文中的标点符号遵循外文的习惯用法(外文的缩写和转行遵循有关规则)