METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF

专利名称：METHODS AND COMPOSITIONS USEFUL

FOR INHIBITION OF alpha v beta 5MEDIATED ANGIOGENESIS

发明人：BROOKS, Peter,CHERESH, David,

A.,FRIEDLANDER, Martin

申请号：EP97927814.0申请日：19970530公开号：EP0907661A1公开日：19990414

摘要：The present invention describes methods for inhibiting angiogenesis in tissuesusing vitronectin alpha v beta 5 antagonists. The alpha v beta 5-mediated angiogenesis iscorrelated with exposure to cytokines including vascular endothelial growth factor,transforming growth factor- alpha and epidermal growth factor. Inhibition of alpha v beta5-mediated angiogenesis is particularly preferred in vascular endothelial ocular

neovascular diseases, in tumor growth and in inflammatory conditions, using therapeuticcompositions containing alpha v beta 5 antagonists.

申请人：The Scripps Research Institute

地址：10550 North Torrey Pines Road La Jolla, CA 92037 US

国籍：US

代理机构：Fisher, Adrian John

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